CLARE is associated with which type of bacteria?

CLARE is associated with which type of bacteria?

• A. Gram-positive cocci only
• B. Gram-negative bacteria
• C. Anaerobes exclusively
• D. Fungi

Answer: (B)

CLARE represents an acute inflammatory reaction in contact lens wearers caused by toxins released by Gram-negative bacteria on lenses or in the tear film. The key point is the involvement of Gram-negative organisms, whose endotoxins (lipopolysaccharides) provoke inflammation of the conjunctiva and cornea. This is why the association is with Gram-negative bacteria rather than Gram-positive cocci, anaerobes, or fungi. Classic culprits include Gram-negative organisms like Pseudomonas, which explains the inflammatory red eye seen in CLARE.

CLARE represents an acute inflammatory reaction in contact lens wearers caused by toxins released by Gram-negative bacteria on lenses or in the tear film. The key point is the involvement of Gram-negative organisms, whose endotoxins (lipopolysaccharides) provoke inflammation of the conjunctiva and cornea. This is why the association is with Gram-negative bacteria rather than Gram-positive cocci, anaerobes, or fungi. Classic culprits include Gram-negative organisms like Pseudomonas, which explains the inflammatory red eye seen in CLARE.